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KMID : 0606319930090010063
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Journal of Phamacetical Sciences Sookmyung Women s University
1993 Volume.9 No. 1 p.63 ~ p.71
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The effect of PtCl4(2-CEen) on α-amylase and pepsin activity
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Abstract
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Abstract:
@EN This study was carried out to know the effect of tetrachloro[bis(2-chloroethyl)ethylenediamine-N,N']platinum(IV) (PtCl4(2-CEen)) on α-amylase and pepsin activity. The comparison of PtCl4(2-CEen) with cisplatin showed at each reaction. After
the
PtCl4(2-CEen) reacted with α-amylase, its antitumor activity was examined. The effect of PtCl4(2-CEen) on α-amylase activity showed inhibition. At high concentration relatively, it appears that the effect of inhibition was high. On the
contrary,
theffect of cisplatin on α-amylase activity showed activation. The relative activity was decreased, according as the concentration of cisplatin increases. The reaction mixture with PtCl4(2-CEen) showed increased activity of pepsin than control.
The
activity of pepsin increased with increased concentration of PtCl4(2-CEen). On the contrary, cisplatin showed the inhibition of pepsin activity. The ratio of inhibition was decreased gradually, according as the concentration of cisplatin
increases.
After the PtCl4(2-Ceen) reacted with α-amylase, its antitumor activity was almost unchanged.
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KEYWORD
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